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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as focusing on practical aspects of designing a study which include the recruitment process and consent, adhering and the use of routinely available equipment.
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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which employed various investigators and had participants from various geographical areas. This type of heterogeneity which is vital for pragmatic trials to be valid and to reduce bias in the results, is also necessary. However excessive heterogeneity could result in issues with the design of the trial.
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The aim of pragmatic trials is to simulate real-life situations and achieve maximum credibility externally. They are typically commissioned by practitioners and policy makers to aid in their decision-making. They can be used to determine the causal relationship between an intervention and its effects. However, they shouldn't be used to substitute for explanation trials.
The idea of pragmatism is controversial, and there are questions about whether pragmatic trials can replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 suggested the distinction between explanation trials, which confirm the clinical or physiological hypothesis as well as pragmatic trials that inform the practice and policy decisions. They also suggested a framework for pragmatic trials, called PRECIS.2 This tool sought to define the elements of a pragmatic trial that include recruitment, design and delivery of the intervention, as well as the follow-up.
There is an encouraging increase in the number pragmatic trials that have been published. A recent Medline query that used the words pragmatic and naturalistic, limited to randomised controlled trials (RCTs) returned 34 articles. They are displayed in red on Figure 2. This indicates that the health sciences community has become more aware of the importance of pragmatic thinking. However, click the following post is important to keep in mind that the majority of these trials were conducted in primary care settings.